The impact of vitamin D supplementation on reproductive outcomes in women with polycystic ovary syndrome: a randomized controlled trial
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Aims: This study aims to evaluate the effectiveness of vitamin D supplementation treatment on reproductive outcomes in women with polycystic ovary syndrome (PCOS). Methods: The study involved 235 women aged 20-40 with PCOS who were seeking treatment at Private infertility Clinic in Turkiye. The participants were divided into two groups: 123 in the control group and 115 in the intervention group, chosen at random. Their age, body-mass index (BMI), education level, employment status, and PCOS symptoms were assessed. Statistical significance between the case and control groups was compared using the chi-squared and Fisher’s exact tests. Results: There were no significant differences in age, BMI, education level, employment status, and PCOS symptoms such as menstrual irregularity, amenorrhea, hirsutism, hair loss and acne between the intervention and control groups (p-value>0.05). There were significant differences in clinical pregnancy rates (CPR) between the intervention and control groups (p-value<0.05). The two groups showed no significant differences in live birth rates and clinical miscarriage rates (p-value>0.05). Conclusion: Based on the findings, it has been revealed that supplementing with vitamin D has a positive impact on CPR. Vitamin D supplementation may support the improvement of fertility in women with PCOS, although the exact mechanisms and effectiveness are still under study.
DOI: 10.51271/jcogp-0046
Authors: Nurgül Ulusoy, Mehmet Ağar, Halime Çalı Öztürk
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4409405455