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Tracheobronchial Amyloidosis: A Rare Airway Disorder With Diagnostic and Therapeutic Challenges—A Case Report and Literature Review

Year: 2025

Type: article

Abstract: Tracheobronchial amyloidosis (TBA) is a rare, localised form of amyloidosis characterised by the extracellular deposition of abnormal proteins within the tracheal and bronchial tissues. This condition, although uncommon, can significantly impact airway function, leading to symptoms such as persistent cough, dyspnea and airway obstruction. This report highlights the clinical presentation, diagnostic approaches and therapeutic options for TBA, emphasising the need for individualised management strategies and comprehensive patient care. This case describes a 62-year-old male with a history of smoking debuting with progressive hoarseness, dyspnea and dysphagia, who was initially diagnosed with tracheobronchial amyloidosis following biopsy of a subglottic mass. After surgical excision and a 3-year disease-free interval, he experienced multiple recurrences requiring further interventions, including bronchoscopic evaluation. Histopathological confirmation of recurrent amyloidosis led to a decision for strict follow-up, as symptoms remained mild post-biopsy.

Source: Respirology Case Reports

DOI: 10.1002/rcr2.70171

Authors: Filip Shterev, Vladimir Aleksiev, Veselin Chonov, Boyko Yavorov, Stanislav Kartev, Dimcho Argirov

Institutions: Plovdiv University, Medical University Plovdiv

Language: English

Topic: Amyloidosis: Diagnosis, Treatment, Outcomes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,130