Year: 2025
Type: article
Abstract: In this Research Highlight, we discuss two recently published studies that show that germinal center B cells undergoing multiple rounds of cell division strongly suppress their rate of somatic hypermutation. These studies provide an explanation for how high-affinity germinal center B cells avoid deleterious mutations that could impair antibody affinity maturation.
Source: Immunology and Cell Biology
DOI: 10.1111/imcb.70022
Authors: Pradhnesh Andhare, Brian J Laidlaw
Institution: Washington University in St. Louis
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4409406291