Work

Expression Patterns of miRNA in the Experimental Autoimmune Encephalomyelitis (EAE)/MS Model Treated With Oenothera biennis Oil

Year: 2025

Type: article

Abstract: Background: Dysregulation of microRNA expression emerges as a crucial factor in the pathogenesis of autoimmune diseases, and their importance in modulating immune responses and disease progression is evident. Methods: This study investigated the expression patterns of miRNAs in the brain tissues of C57BL/6J mice using the experimental autoimmune encephalomyelitis (EAE) model, which mimics multiple sclerosis (MS). The model was treated with Oenothera biennis oil, a potential therapeutic agent. Results: Our research has revealed a novel and significant likelihood of association between miR‐182‐5p, miR‐200c‐3p, miR‐206‐3p, miR‐429‐3p, miR‐1298‐5p, and diseases resembling the EAE model, such as MS. This groundbreaking discovery could have profound implications in diagnosing and treating autoimmune diseases that mimic the EAE animal model. Conclusions: These miRNAs, identified in our study, might serve as potential therapeutic targets in MS, potentially leading to more effective treatments and improved patient outcomes.

Source: Acta Neurologica Scandinavica

DOI: 10.1155/ane/3001118