Year: 2025
Type: article
Abstract: MSCS -CentrAl eleMent Of preSerVAtIOn-reStOrAtIOn SySteMThe extensive study of MSCs as therapeutic agents has revealed a wide range of different mechanisms of their interaction with other cells.It turned out that MSCs actively interact not only with the cells of immune system, modulating, for example, the inflammatory response, but also with the cells of damaged or altered tissues, supporting them and triggering healing and regeneration processes.Until now, the study and use of MSCs have occurred mainly after their expansion ex vivo.However, due to the high epigenomic plasticity of these cells, dependent on environmental signals, when cultured ex vivo, these cells have time to change so much that this does not allow direct extrapolation of the effects they exhibit to understanding their natural role in vivo.Nevertheless, based on the totality of the data already obtained, we make a provocative assumption about the central place of MSCs in ensuring recovery/regeneration events in the body.In addition, it should be noted that not all effects described to date fit into the established paradigm of cell division by functional features, since the phenomenon of MSCs is rather not a cell type, but a state into which various highly plastic cells surrounding vessels can pass.This indicates a possible need to revise some established concepts and may lead to the allocation of the provision of restoration/reparation processes into a separate system of preservation and restoration of the body.
Source: Biopolymers and Cell
DOI: 10.7124/bc.000b10
Authors: V. A. Kordium, D. M. Irodov
Institution: Institute of Molecular Biology and Genetics
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409408172