Work

L-Carnitine and Acetyl-L-Carnitine: A Novel Approach to Treating Male Infertility with Abnormal Sperm Morphology

Year: 2025

Type: article

Abstract: This case report presents a 36-year-old man with elongated sperm morphology, a specific type of teratozoospermia, associated with oxidative stress and deoxyribonucleic acid (DNA) damage. Six months of supplementation of L-carnitine, acetyl-L-carnitine, CoQ10, zinc, and vitamins, combined with lifestyle modifications enhanced sperm motility, morphology, and quality significantly. Posttreatment semen analysis showed improved concentration (13-20 million/mL), progressive motility (25%-40%), and normal morphology (2%-7%). The couple underwent intracytoplasmic morphologically selected sperm injection (IMSI), leading to successful fertilization, production of high-quality embryos, and confirmed pregnancy. This case illuminates the therapeutic potential of L-carnitine and acetyl-L-carnitine supplementation, in combination with IMSI, in treating male infertility associated with abnormal sperm morphology and improving outcomes of assisted reproductive technology.

Source: Journal of Pharmacy And Bioallied Sciences

DOI: 10.4103/jpbs.jpbs_256_25

Authors: Lakhan Parsharam Padwal, Akash More, Namrata Choudhary, Ganesh Laxman Kalasakar, Tejaswini Wadhe

Institution: Datta Meghe Institute of Higher Education and Research

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $250