Work

Population pharmacokinetic analysis of tobramycin in serum and ELF using data from patients with pneumonia

Year: 2025

Type: article

Abstract: ABSTRACT Population pharmacokinetic analyses were undertaken to characterize epithelial lining fluid (ELF) penetration for tobramycin in pneumonia patients. A two-compartment model with zero-order intravenous input and first-order elimination linked to an effect site ELF compartment was utilized to determine the steady-state ELF penetration ratio of 0.51 for tobramycin. These results are useful to account for effect site exposure when performing analyses to support recommendations for aminoglycoside dosing regimens and interpretive criteria for in vitro susceptibility testing.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00908-24

Authors: Scott A. Van Wart, Michael Trang, M. Courtney Safir, Andrew R. Santulli, Christopher M. Rubino, Sujata M. Bhavnani

Institution: Institute for Clinical Pharmacodynamics (United States)

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409411315

FWCI: 0.989

Cites: 17

Cited by: 2

Related to: 10