Work

Naphthalene-dicyanoisophorone hybrid fluorescent probe for detection of hypochlorite based on cyclization mechanism

Year: 2025

Type: article

Abstract: Fluorescent probe is a powerful tool for studying hypochlorite (ClO−) effects in biological systems. Here we reported a novel fluorescent probe NP for the sensing of ClO− with a low detection limit (78 nM) and large Stokes shift (170 nm). Mechanism studies demonstrated an amine ring-forming process, resulting in a pyrrole ring structure that caused the fluorescence enhancement. Furthermore, NP was successfully used to imagine both endogenous and exogenous ClO− in living cells and mice. This study provided a new opportunity for construction of ClO− fluorescent probe application in biomedical imaging and biosensing.

Source: Sensors and Actuators B Chemical

DOI: 10.1016/j.snb.2025.137808

Authors: Mengjie Liu, Yanjin Wang, Miaoyu Wang, Pengfei Cheng, Kuoxi Xu

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,010

Funders: Henan University, Henan Provincial Science and Technology Research Project

Award: G3114817202