Work

The effect of amphiregulin on equine endometrial fibroblasts: in vitro responses of fibroblast derived from non-fibrotic and fibrotic endometrium

Year: 2025

Type: article

Abstract: The role of AREG in the development of fibrosis in the progression of endometrosis in mare remains unknown. We aimed to determine the effects of AREG on fibroblast functional characteristics as well as the expression of extracellular matrix (ECM)-associated genes in fibroblast derived from non-fibrotic and fibrotic equine endometria. Our findings suggest that the mechanisms associated with ECM remodeling regulated by AREG in non-fibrotic fibroblasts may be dysregulated in the progression of fibrosis in endometrosis.

Source: Reproductive Biology

DOI: 10.1016/j.repbio.2025.101018

Authors: Anna Wójtowicz, Agnieszka Sadowska, Katarzyna Piotrowska-Tomala, Anna Szóstek-Mioduchowska

Institutions: InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Polish Academy of Sciences

Language: English

Topic: Reproductive Physiology in Livestock

Subfield: Agronomy and Crop Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,750