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Synthesis of Substituted Imidazo[1,2‐a]pyridines, Imidazo[1,2‐a]pyrazines and Imidazo[1,2‐b]pyridazines by Multicomponent Reactions Using Green Solvents

Year: 2025

Type: article

Abstract: Herein, the synthesis of imidazo[1,2‐a]pyridines, imidazo[1,2‐a]pyrazines and imidazo[1,2‐b]pyridazines by a multicomponent Groebke–Blackburn–Bienaymé reaction is described under sustainable conditions using eucalyptol as green solvent. After determining the optimum conditions for catalysis, a library of 32 compounds with activity on the central nervous system was quickly and efficiently assembled.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500343

Authors: Abdelkarim El Qami, Gatien Messire, Gaëtan Bouchery, Emma Caillet, Sloan Steiner, Sabine Berteina‐Raboin

Institutions: Université d'Orléans, Centre National de la Recherche Scientifique, Institut de Chimie Organique et Analytique

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

Funders: Agence Nationale de la Recherche, Centre National de la Recherche Scientifique, Université d'Orléans