Glutathione/Cysteine Dual‐Consuming Prodrug Nanoassemblies for Potentiated Gas‐Photodynamic Therapy
Year: 2025
Type: article
Abstract: Tuning the oxidative stress‐defense system plays a vital role in the treatment of breast tumors. In this study, a pyropheophorbide‐a (PPa)‐based prodrug nanoassembly is constructed by linking PPa with furoxan, a cysteine‐depleting nitric oxide (NO) donor, through a disulfide bond. The as‐prepared prodrug (NOSP) can assemble with distearoyl phosphoethanolamine‐PEG 2000 (DSPE‐PEG 2000 ) to form nanoassemblies in aqueous media. Following internalization by tumor cells, NOSP can respond to cysteine (Cys) and induce NO release to activate endogenous matrix metalloproteinases (MMP‐1, ‐2), leading to collagen degradation and improved drug delivery. In addition, Cys consumption can impede the biosynthesis of glutathione (GSH), while NOSP can react with high levels of intracellular GSH within seconds, thus synergizing photodynamic therapy against breast tumors and distant metastasis.
Source: Advanced Functional Materials
Authors: Ning Tang, Fan Tong, Panchenghao Wu, Xiaofang Xie, Lulu Wang, Miao Yu, Xiaoyun Xing, Honglei Wang, Hao Wang, Huile Gao, Chuan Hu, Cheng Peng, Yang Zhou
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
Award: G2045993879
OpenAlex ID: W4409415932