Work

Tumefactive and longitudinally extensive myelitis: A rare presentation of multiple sclerosis?

Year: 2025

Type: article

Abstract: Cerebral tumefactive demyelinating lesions are well described in multiple sclerosis (MS). Yet few cases of MS-associated tumefactive spinal cord demyelination have been described. We report a patient with a clinical course typical of relapsing-remitting MS who presented with a relapse associated with a tumefactive and longitudinally extensive cervical spinal cord lesion. Despite extensive evaluation, and with two years of longitudinal follow up, no better explanation than MS could be identified. This case highlights the diagnostic and prognostic challenges associated with presumed tumefactive spinal cord demyelination in MS, and the unmet need for further cases to guide therapeutic decision-making.

Source: Neuroimmunology Reports

DOI: 10.1016/j.nerep.2025.100257

Authors: Adam L. Morehead, Eoin P. Flanagan, Andrew J. Solomon

Institutions: University of Vermont, Mayo Clinic

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,120