Differential Urinary Proteomics and Absolute Protein Quantification Reveal Biomarkers of Muscle-Invasive and Non-Muscle-Invasive Bladder Cancer
Year: 2025
Type: article
Study design: Observational Study
Abstract: A comparative urinary proteomic analysis using the Total Protein Approach (TPA) revealed distinct protein abundance profiles between patients with muscle-invasive (MIBC) and non-muscle-invasive bladder cancer (NMIBC), suggesting potential diagnostic utility. Notably, several proteins, including periostin (POSTN), immunoglobulin variable regions (IGLV3-21, IGHV3-49, IGHV5-51), and complement regulator (C4BPB), were found at significantly higher concentrations in the urine of MIBC patients. These findings support their value as non-invasive indicators of tumour aggressiveness. The TPA-based urinary protein signature holds promise for improving early risk stratification, detecting biological features associated with invasive disease, and may inform treatment strategies.
Source: Journal of Integrated OMICS
Authors: João M. R. A. Montes, Luís B. Carvalho, Inês F. Domingos, André Q. Figueiredo, Carlos Lodeiro, Mariana Medeiros, Luís Campos Pinheiro, José Luís Capelo Martínez, Hugo M. Santos
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: G1240268737, G138060719, G1509028180, G1522114529, G1977608718, G2012127377, G2339299466, G2346795057, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, G2756637201, G2783038177, G2814222956, G3127682330, G3285476938, G332082475, G3731782831, G4046065984, G4378797157, G4693354510, G5366951229, G5668020402, G567200461, G5832795443, G5868090805, G6113984419, G6119126181, G6463117426, G6625491009, G6997658380, G7786427436, G8213652065, G824076568, G8628921259, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, G8963217260
OpenAlex ID: W4409427240