Effectiveness of Early Cardiorespiratory Rehabilitation Combined With Melatonin Supplementation During the Inpatient Period After Acute Myocardial Infarction: a Pilot Study
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Objective: To investigate the safety and effectiveness of early cardiopulmonary rehabilitation (ECR) combined with melatonin supplementation on functional capacity and sleep quality during hospitalization in patients with acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (PCI). Design: Single-blinded randomized controlled trial. Setting: Cardiology inpatient unit where patients were hospitalized after PCI. Participants: Forty-eight male patients (N=48) with AMI followed by PCI (mean age of 57.1±8.7y) were included and randomized into 3 groups: MELEX (ECR combined with 4 mg of exogenous melatonin), EX (ECR with placebo), and CON (control group with placebo). Interventions: Patients in the MELEX and EX groups participated in ECR, consisting of walking, passive and active range of motion, moderate-intensity strengthening exercises, and breathing exercises. The MELEX group received a daily 4 mg dose of melatonin, while the EX and CON groups received a placebo. Participants in CON group received usual care without engaging in ECR. Main Outcomes Measures: Functional capacity was evaluated by the 6-minute walking test (6mwt). Sleep quality was assessed by the Spiegel questionnaire. Rating of perceived exertion was evaluated using the Borg Scale. Assessments were conducted on the first day after PCI and at hospital discharge. Results: <.001). No adverse cardiac events related to ECR or melatonin supplementation were recorded during hospitalization. Conclusions: ECR combined with a daily 4 mg of melatonin supplementation was safe and effective in improving functional capacity and sleep quality in patients with AMI during hospitalization after PCI.
Authors: Mohamed Ali Hbaieb, Salma Charfeddine, Tarak Driss, Laurent Bosquet, Benoit Dugué, Leila Abid, Omar Hammouda
Institutions: University of Sfax, Université de Poitiers, Institut Supérieur du Sport et de l’Éducation Physique de Sfax, Faculty of Medicine of Sfax, Laboratoire Mobilité Vieillissement et Exercice, Hopital Universitaire Hedi Chaker, Université Paris Nanterre, Laboratoire interdisciplinaire en neurosciences, physiologie et psychologie
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,500
OpenAlex ID: W4409428935