Year: 2025
Type: article
Abstract: We report the design and application of a monofluoromethylation reagent: 1‐((bromofluoromethyl)sulfonyl)‐4‐chlorobenzene. By taking advantage of the electron‐withdrawing property of the sulfonyl group, the polarity of the monofluoride radical can be regulated; moreover, the sulfonyl group's facile removability is exploited. These combined features enable direct monofluoromethylation of (hetero)arenes under mild visible‐light conditions.
Authors: Zechao Liu, Xuefeng Gu, Huiming Dai, Chuangchuang Liu, Yilian Song, Xin Liu, Zhibin Huang, Yingsheng Zhao
Institution: Soochow University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Award: G1577625030
OpenAlex ID: W4409430461