Work

Immune Response Activation and Hepatoprotective Activity of Randia echinocarpa Soluble Melanins in Murine Models

Year: 2025

Type: article

Abstract: This research demonstrates the in vivo immunomodulatory and hepatoprotective activities of the soluble melanins of the Randia echinocarpa fruit (PSM). The splenocyte cellular metabolic activity and lymphocyte T γδ expression in mesenteric lymph nodes (MLNs) and Peyer patches (PPs) were measured in the mice model. The PSM hepatoprotective activity was evaluated in the CCl 4 ‐induced acute hepatotoxic injury (AHTI) in the rat model. Compared with the controls, the PSM treatment induced higher splenocyte cellular metabolic activity (in vitro, 24.1%–57.25%; in vivo, 28.8%–47.7%), activation of lymphocytes T γδ in MLN but suppression in PP. Related to in vivo hepatoprotective activity, PSM treatment reduces CCl 4 ‐induced damage; animals showed lower levels of serum ALT (218.85–67.02 U/L) and ALP (453.37–355.47 U/L), higher levels of serum GSH (127.96–252.15 ng/mg of tissue), lower levels of hepatic MDA (10.25–7.85 nmol/mL), and less severe damage in the hepatic histopathology. These results suggest the nutraceutical and therapeutic potential of PSM.

Source: International Journal of Food Science

DOI: 10.1155/ijfo/5888390

Authors: María del Rosario Gil-Avilés, Sylvia Paz Díaz-Camacho, Ulises Osuna-Martínez, Gabriela López-Angulo, Francisco Delgado-Vargas

Institutions: Universidad Autónoma de Occidente, Universidad Autónoma de Sinaloa

Language: English

Topic: Medicinal Plant Research

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $860