Year: 2025
Type: article
Abstract: Results: Twenty-three patients (15 men and 8 women) with a median age of 57 years were enrolled, with 87.5% having the JAK617F mutation. Six patients had a history of thrombosis. Besremi was used as a first-line treatment in 11 patients and as a second-line treatment in 12 patients after Hydroxyurea administration. Complete hematologic response, defined by normalized blood counts and symptom resolution, was achieved in 3.46 ± 2.53 months in more than 50% of patients. One patient discontinued treatment, two did not achieve complete response, and four had less than 3 months of follow-up. After 6 months, the mean hematocrit was 44.17 ± 7.76 (p = 0.01), WBC 7.6 ± 3.92 x 1000/mmc (p = 0.02), and thrombocytosis significantly decreased in the first month (p = 0.02). Conclusions: Ropeginterferon treatment improved the quality of life for all patients, eliminating symptoms of cardiovascular and thrombotic complications. Approximately 60% of patients achieved complete hematologic response within the first 3 months.
Authors: Diana GRASU, Viola Maria POPOV, Mirela VOICU, Mihaela POPESCU, Oana PATRINOIU, Felicia MIHAI, Geanina OFITERU, Meilin OMER, Mihaela ANDREESCU
Institutions: Spitalul Clinic Colentina, Titu Maiorescu University
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409433687