Work

Incremental diagnostic value of coronary computed tomography angiography derived fractional flow reserve to detect ischemia

Year: 2025

Type: article

Abstract: Over the past decade, coronary computed tomographic angiography (CCTA) has been the most robust non-invasive method for evaluating significant coronary stenosis. Thanks to new technologies, it is now possible to determine the fractional flow reserve (FFR) non-invasively using computed tomographic (CT) images. The aim of this work was to evaluate the incremental diagnostic value of CT-derived FFR for ischemia detection. In this retrospective monocentric study, we investigated 421 patients who underwent CCTA and subsequent ischemia testing between 04/2009 and 06/2020. Endpoint was ischemia on a coronary vessel level assessed by CMR ( n = 20), SPECT ( n = 225), invasive angiography (stenosis ≥ 90%; n = 80) or invasive FFR (positive if ≤ 0.8; n = 96). CT-FFR was derived from CCTA images by a machine learning (ML) based software prototype. Patients averaged 66.5 [58.2–73.6] years of age and 72.7% ( n = 306) were male. Overall, 52.5% ( n = 221) had hypertension and 67.9% ( n = 286) had hypercholesteremia. Logistic regression analysis on a per vessel base showed that the diagnostic model with CT-FFR plus CCTA had significantly better-fit criteria than the diagnostic model with CCTA alone (log-likelihood χ 2 230.21 vs. 192.17; p for difference < 0.001). In particular, the area under curve (AUC) by receiver operating characteristics curve (ROC) analysis for CT-FFR plus CCTA (0.87) demonstrated greater discrimination of hemodynamic ischemia compared to CCTA alone (0.83; p for difference < 0.0001). Combined CCTA and CT-FFR have improved diagnostic accuracy compared to CCTA alone in detecting ischemia on the coronary vessel level and thus could reduce the use of invasive coronary angiography in the future.

Source: Scientific Reports

DOI: 10.1038/s41598-025-95597-4