Work

Oxo-Hydrazyl as a Substitute for the Stable Free Radicals Employed in Measuring Total Antioxidant Activity

Year: 2025

Type: article

Abstract: Numerous standardized methods for evaluating antioxidant capacity are available, some of the most used methods in this regard employ stable free radicals, like 2,2-diphenyl-1-picrilhydrazyl free radical (DPPH·) or 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid cation radical (ABTS·+). However, some challenges can arise in taking correct and reproducible measurements due to the well-known unspecific reactivity of these free radicals. In pursuit of improving and expanding such methods, in this work is proposed a highly intense colored zwitterionic derivative of the DPPH· free radical, as a replacement for DPPH· and ABTS·+ derivatives. A discussion and comparison of the recognized methods are presented, demonstrating the very good potential of this non-radical compound.

Source: Antioxidants

DOI: 10.3390/antiox14040463

Author: Petre Ionita

Institution: University of Bucharest

Language: English

Topic: Free Radicals and Antioxidants

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,499

Funder: Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii