Work

Sodium butyrate attenuates experimental neonatal necrotizing enterocolitis by suppressing TLR4-mediated NLRP3 inflammasome-dependent pyroptosis

Year: 2025

Type: article

Abstract: cell model (LPS-stimulated IEC-6 cells) was then established to confirm the docking results. Results using assays involving the NLRP3 (MCC950) and TLR4 (TAK-242) inhibitors suggested that NaB protected intestinal cells from inflammatory injuries during NEC by suppressing the TLR4/MyD88/NF-κB/NLRP3/cleaved caspase-1/GSDMD inflammasome pathway. These findings indicated that NaB can be used as a potential modulatory and therapeutic candidate for the treatment of NEC.

Source: Food & Function

DOI: 10.1039/d4fo03517h

Authors: Yanan Gao, Liting Yang, Hongya Wu, Qianqian Yao, Jiaqi Wang, Nan Zheng

Institutions: Chinese Academy of Agricultural Sciences, Institute of Animal Sciences, Institute of Food Science and Technology, University of Liège

Language: English

Topic: Infant Nutrition and Health

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: China Agricultural Research System, National Key Research and Development Program of China, Agricultural Science and Technology Innovation Program