Work

Osteomyelitis Caused by Moesziomyces aphidis in an Immunocompetent Adult: A Case Report and Literature Review

Year: 2025

Type: article

Abstract: Osteomyelitis caused by Moesziomyces aphidis is exceedingly rare and, to our knowledge, has not been previously reported in immunocompetent individuals. This case represents the first documented instance. A 19-year-old woman developed osteomyelitis following an open right leg fracture sustained in a traffic accident. Initial cultures yielded an unidentified yeast, later identified as M. aphidis through internal transcribed spacer sequencing. The patient demonstrated clinical improvement with combination therapy of amphotericin B and following oral voriconazole. This case underscores the emerging pathogenic potential of Moesziomyces spp., particularly in the setting of trauma and open wounds, and highlights the importance of including this genus in the differential diagnosis of osteomyelitis. A literature review indicates that Moesziomyces infections are predominantly observed in immunocompromised patients, especially in Asia. However, our case underscores the need for greater awareness of this emerging pathogen in immunocompetent hosts as well.

Source: Tropical Medicine and Infectious Disease

DOI: 10.3390/tropicalmed10040107

Authors: Yi-Ying Chen, Ting-Kuang Yeh, Chi-Jung Wu, Po-Yu Liu

Institutions: Taichung Veterans General Hospital, National Health Research Institutes, National Chung Hsing University

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258