Year: 2025
Type: conference-abstract
Abstract: Introduction: Vitamin D plays an essential role in regulating cell proliferation and apoptosis and has been linked to several obstetric complications.The aim of the study is to assess whether vitamin D dosage and supplementation can improve perinatal outcomes in twin pregnancy that is at high risk per se.Materials and methods: This retrospective study included twin pregnancies followed by the Twin Pregnancy Care Unit of Sant'Anna Obstetric-Gynecological Hospital in Turin between 2020 and 2023.In one group serum vitamin D was measured in the first trimester and, if needed, supplementation was administered.In the second group vitamin D was not measured nor supplemented.First, we compared perinatal outcomes between the two groups.Then, we assessed whether vitamin D status (insufficient, deficient, sufficient) in the first trimester could influence pregnancy outcomes.Results: Serum vitamin D was dosed (and, if appropriate, supplemented) in 146 of the 278 twin pregnancies included in our study in the first trimester.Pregnancies in which vitamin D was not dosed had a higher incidence of hypertensive disorders of pregnancy (HDP, 22.7% vs. 16.7%,p = .042)and birth weight discordance (11.4 ± 8.4 % vs. 7.3 ± 4.2 %, p = .036),while no difference was found between the two groups in mode of delivery, gestational age at birth, neonatal birth weight, incidence of IUGR and gestational diabetes.Vitamin D status in the first trimester was significantly associated to a higher rate of HDP: incidence of HDP was 29.4% in insufficient women, 25.3% in deficient ones and 16.0% in sufficient ones (p = .045).Conclusions: Assessment of vitamin D status and subsequent supplementation is associated to a reduction in the incidence of HDP and a decreased birth weight discordance in twin pregnancy.Vitamin D status in the first trimester appears to be significantly related to incidence of HDP later in pregnancy.
Source: Twin Research and Human Genetics
DOI: 10.1017/thg.2025.12
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $1,665
OpenAlex ID: W4409439232