Spatial proteomics in translational and clinical research
Year: 2025
Type: article
Abstract: Spatial proteomics offers unprecedented insights into the localization, quantity, and interactions of proteins within cells and tissues, thereby enabling researchers and clinicians to map protein networks with high precision. This powerful approach is currently revolutionizing our understanding of cellular organization and function (Method of the Year 2024: spatial proteomics, 2024), and providing deeper insights into how protein distribution and dynamics contribute to physiological and pathological processes. Here, we discuss recent advances in targeted and untargeted (exploratory) spatial proteomics, shed light on emerging multiscale approaches for tissue profiling, and highlight their translational potential.
Source: Molecular Systems Biology
Authors: Peter Horvath, Fabian Coscia
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $7,990
Awards: G1147627523, Deep Spatial Proteomics: connecting cellular neighbourhoods to functional states, G3476556667, G357071512, G4375117835, Fast Infrared Coherent Harmonic Microscopy, G534308451, G5483924367, SWEEPICS: SWEPT LASERS FOR NON-INVASIVE DIAGNOSTICS, G7694217703, G7933988404, G7957566972, G8514866780
OpenAlex ID: W4409439521