Work

Co-Deposited Proteins in Alzheimer’s Disease as a Potential Treasure Trove for Drug Repurposing

Year: 2025

Type: article

Abstract: Alzheimer's disease (AD) affects an increasing number of people as the human population ages. The main pathological feature of AD, amyloid plaques, consists of the key protein amyloid-β and other co-deposited proteins. These co-deposited proteins and their protein interactors could hold some additional functional insights into AD pathophysiology. For this work, proteins found on amyloid plaques were collected from the AmyCo database. A protein-protein and protein-drug interaction network was constructed with data from the IntAct and DrugBank databases, respectively. In total, there were 12 proteins co-deposited on amyloid plaques that reportedly interact with 513 other proteins and are targets of 72 drugs. These drugs were shown to be almost entirely distinct from the panel of drugs currently approved by the FDA for AD and their corresponding protein targets. In conclusion, this work demonstrates the potential for drug repurposing of drugs that target proteins found in amyloid plaques.

Source: Molecules

DOI: 10.3390/molecules30081736

Authors: Avgi E. Apostolakou, Dimitra E. Douska, Zoi I. Litou, Ioannis P. Trougakos, Vassiliki A. Iconomidou

Institution: National and Kapodistrian University of Athens

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258