Is Single or Multiple Gallbladder Stones a Coincidence or Related to Any Contributory Factor
Year: 2025
Type: article
Abstract: Stone disease is one of the most widespread gastrointestinal diseases and burdens healthcare systems considerably. It is expected to increase in aging populations at risk. Gallbladder stone formation is a multifaceted metabolic disorder. It is an unclear critical pathogenic mechanism. The gallstone formation is due to multiple environmental influences, common genetic factors, and their interactions. Due to that, primary or secondary prevention schemes are not possible, except for cholecystectomy. Data from recent identical twin, family, and linkage studies offer definite evidence for a strong genetic component to gallstone disease. This review summarizes recent data on the role of genetic, gallbladder, and gut motility with biliary lipid composition in either single- or multiple-stone formation.
Source: Haryana Journal of Surgery
DOI: 10.4103/hjs.hjs_1_25
Authors: Sunder Goyal, Snigdtha Goyal
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4409441672