Diagnostic value of tumor markers combined with different imaging protocols for ovarian tumors
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: To investigate the value of ultrasound Gynecological Imaging Reporting and Data System (GI-RADS) classification and Ovarian Reporting and Data System (O-RADS) classifications combined with serum tumor markers for ovarian tumors. Methods: A total of 100 patients with ovarian adnexal tumors had serum tumor markers tested and O-RADS and GI-RADS classifications were used for diagnoses. This allowed for a comparison of the diagnostic efficacy of separate and combined diagnostic approaches. Results: Among the 100 patients, 62 benign masses and 38 malignant masses were identified. Clinical characteristics showed that age, irregular contour and the presence of ascites were significantly different between the benign and malignant groups. The diagnostic efficacy results showed that the sensitivity, specificity, and accuracy of O-RADS combined with GI-RADS classification, human epididymal protein 4 (HE4) and cancer antigen 125 (CA125) were higher than other separate diagnosis and combined diagnosis schemes. Receiver operating characteristic (ROC) curve analysis also confirmed that this approach had better diagnostic efficacy for ovarian tumors. Conclusions: Serum tumor markers HE4, CA125 test, O-RADS classification and GI-RADS classifications provided high diagnostic value for detecting benign and malignant ovarian tumors. However, combining these classifications with HE4 and CA125 further enhanced diagnostic accuracy.
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409442144