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Carbene-catalyzed enantioselective construction of a quasi-symmetrical spirocyclic hydroquinone with a minor chiral distinction

Year: 2025

Type: article

Abstract: An N -heterocyclic carbene–catalyzed enantioselective benzannulation reaction was developed for the synthesis of quasi-symmetrical spirocyclic hydroquinones, including the natural antibiotic fredericamycin A and its analogs.

Source: Chemical Science

DOI: 10.1039/d5sc01605c

Authors: Panlong Ren, Qing Zhao, Yonggui Robin Chi, Tingshun Zhu

Institutions: Sun Yat-sen University, Nanyang Technological University, Guizhou University

Language: English

Topic: N-Heterocyclic Carbenes in Organic and Inorganic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Research Foundation, National Research Foundation Singapore, Ministry of Education - Singapore, Nanyang Technological University, National Natural Science Foundation of China, Sun Yat-sen University, Ministry of Education, India, Guangdong Provincial Key Laboratory of Construction Foundation

Awards: G1174364401, G1482925484, G2212741405, G2342870495, G2407622893, G2410909804, G3048563442, G3641044699, G3882347383, G446957705, G5069063760, G518567468, G5364178476, G6854926366, G7241363003

OpenAlex ID: W4409443036

FWCI: 0.894

Cites: 54

Cited by: 3

Related to: 10