Work

New Insights Into the Human Dopamine Transporter: Structure, Function, and Therapeutic Potential

Year: 2025

Type: article

Abstract: Recently, three breakthrough studies on the structure and function of the human dopamine transporter (hDAT) were published consecutively in Nature [1-3].Researchers used cryoelectron microscopy to resolve high-resolution structures of hDAT bound to various ligands, including dopamine (DA), methylphenidate (MPH), β-CFT, GBR12909, MRS7292, benztropine, and cocaine.The resolution of these structures revealed the detailed molecular mechanism of hDAT in DA reuptake and inhibition, providing important information to guide the development of drugs for the treatment of DA-related diseases.

Source: MedComm

DOI: 10.1002/mco2.70187

Authors: Qi Weng, Qi Wu, Quan Zheng

Institution: Wenzhou Medical University

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,500