Work

Mitochondrial mayhem: Disrupting conserved N-terminal motifs in TANGO2 impacts its localization and function

Year: 2025

Type: article

Abstract: TANGO2 deficiency in humans leads to progressive neurological impairment, punctuated by life-threatening metabolic crises. In this issue, Lujan and colleagues demonstrate that TANGO2 localizes within the mitochondrial lumen and binds acyl-CoA species, potentially implicating it as a lipid trafficking protein.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.202503010

Authors: Sarah E. Sandkuhler, Samuel J. Mackenzie

Institutions: University of Rochester Medicine, University of Rochester

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Arthur J. Schmitt Foundation, Genentech