Light-Induced Electrode Scanning Microscopy
Year: 2025
Type: article
Abstract: Patch clamps and microelectrode arrays have been widely used to detect the electrical properties of cells in biomedicine. Yet, both technologies can record signals only in an invasive manner or at fixed positions. Based on the resolution (LAPS) and optically induced dielectrophoretic, we present a novel light-induced electrode scanning microscopy. It works like a "radar", scans the whole area with living cells in culture, and detects the electrical signals of single cells on a photosensitive chip. In the system, a light pattern projected onto the chip is used to form the corresponding light-induced electrode, and the electrode scanning mode is implemented by moving the light pattern or the chip position for the measurement of the electrical characteristics of biological cells and cell localizations. It provides a new tool for the detection of cell electrical properties and is expected to become the next generation of electrophysiological detection technology.
Source: Analytical Chemistry
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Funders: National Natural Science Foundation of China, China Scholarship Council, Higher Education Discipline Innovation Project, Zhongshan Science and Technology Bureau, HORIZON EUROPE Framework Programme, National Key Research and Development Program of China, Jilin Scientific and Technological Development Program
OpenAlex ID: W4409447498