Work

Associations between dietary inflammatory index with menopause and hysterectomy: findings from a national health and nutrition examination survey

Year: 2025

Type: article

Abstract: BACKGROUND: Although the dietary inflammatory index (DII) plays a vital role in human health, the association between the DII and women's menopausal status is still unclear. The aim of this study was to investigate the associations of the energy-adjusted DII (E-DII) with natural menopause and hysterectomy among women aged 20-65 years in the National Health and Nutrition Examination Survey (NHANES). METHODS: We conducted a cross-sectional study to assess the associations of the E-DII with natural menopause and hysterectomy using multivariate regression models. To further explore the effect of the E-DII on early natural menopause, subgroup analyses were performed. Additionally, the correlations between the E-DII score and age at menopause or hysterectomy were evaluated via Spearman correlation analysis. RESULTS: Data from 9469 women were included in this study. After full adjustment, we observed a positive association between the E-DII and early natural menopause. The odds ratios (ORs) for quartile 4 and quartile 1 were 1.552 (95% CI: 1.043, 2.309) and 1.328 (0.767, 2.301), respectively. We also found positive evidence that the E-DII was associated with hysterectomy. The OR was 1.487 (1.069, 2.069) in quartile 3 versus quartile 1 and 1.729 (1.198, 2.497) for quartile 4 versus quartile 1. The correlation coefficients of the E-DII between the ages of menopause and hysterectomy patients were - 0.12 and - 0.11, respectively. CONCLUSIONS: Our findings suggest that a higher E-DII strongly influences early natural menopause and hysterectomy, likely leading to their earlier onset. However, longitudinal studies or randomized clinical trials are necessary to further confirm our findings.

Source: BMC Public Health

DOI: 10.1186/s12889-024-21235-9