Global Trends in CD4 Measurement and Immunosuppression at ART Initiation Among Children With HIV
Year: 2025
Type: article
Study design: Observational Study
Abstract: Eligibility for antiretroviral therapy is no longer based on immune criteria. In a global cohort of 97,453 children, between 2005 and 2021, we observed large declines in CD4 measurement, from 51% to 12% among <5 seconds, and from 74% to 20% among those 5-14 years of age. Lack of CD4 testing may negatively affect clinical care and surveillance of severe immune suppression.
Authors: Gabriela Patten, Karen Malateste, Carolyn Bolton Moore, Nosisa Sipambo, Limpho Mokone, Nanina Anderegg, Kara Wools-Kaloustian, Denna Michael, Francesca Odhiambo, Charles Kasozi, Sophie Desmonde, Madeleine Amorissani-Folquet, Valériane Leroy, Dewi Kumara Wati, Revathy Nallusamy, Aarti Kinikar, Du Tuan Quy, Marcel Yotebieng, Peter Vanes Ebasone, Patricia Lelo, Jorge Pinto, Vanessa Rouzier, Daisy Maria Machado, Nel Jason Haw, Nathan Ford
Institutions: University of Cape Town, Université de Bordeaux, Inserm, Bordeaux Population Health, Institut de Recherche pour le Développement, Centre for Infectious Disease Research in Zambia, University of the Witwatersrand, Chris Hani Baragwanath Hospital, SolidarMed, University of Bern, Indiana University School of Medicine, National Institute for Medical Research, Kenya Medical Research Institute, Masaka Hospital, Université de Toulouse, Centre d'Epidémiologie et de Recherche en santé des POPulations de Toulouse, Centre Hospitalier Universitaire de Cocody, Udayana University, B. J. Medical College & Sassoon Hospital, Children's Hospital 1, Albert Einstein College of Medicine, Universidade Federal de Minas Gerais, Gheskio Centers, Universidade Federal de São Paulo, Johns Hopkins University, World Health Organization
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G240136927, G2466661058, G295270083, G325158278, G596821015, Emory Specialized Center of Research Excellence (SCORE) on Sex Differences, Central Africa International Epidemiology databases to Evaluate AIDS, Caribbean, Central, and South America network for HIV Epidemiology (CCASAnet), International Epidemiology Databases to EvaluateAIDS (IeDEA) Renewal 4
OpenAlex ID: W4409450950