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When the Treatment Becomes the Problem: A Case of Paradoxical Case Effects of IVIG

Year: 2025

Type: article

Abstract: Intravenous immunoglobulin (IVIG) is commonly used for immunomodulation in autoimmune diseases but can induce rare complications, such as hemolytic anemia. We report a case of a 19-year-old woman with Crohn disease complicated by pyoderma gangrenosum, presenting with IVIG-induced hemolytic anemia and a distinctive rash. Following two doses of IVIG, she experienced headaches, rash, and tachycardia. Laboratory findings showed anemia, hyperbilirubinemia, and a positive Coombs test. She was managed with supportive care. This case underscores the need for vigilant monitoring for hemolysis in patients receiving IVIG, especially those with cumulative doses and underlying inflammatory conditions.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2024.1195

Authors: Rupayan Kundu, Mikinzi Casto, Alyson M. Rich, Genesys Santana, Richard M. Wardrop

Institutions: Cleveland Clinic, West Virginia University, Case Western Reserve University, University Hospitals of Cleveland

Language: English

Topic: Blood groups and transfusion

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409451434

FWCI:

Cites: 7

Cited by:

Related to: 10