Year: 2025
Type: article
Abstract: Rapid urbanization, mechanization and automation of labor activity and everyday life in recent decades has led to the spread of physical inactivity and, as a result, to the development of venous syndromes in the younger population of the world. The pharmacological effect of phlebotonics is aimed at normalizing vascular wall permeability, improving the rheological properties of blood and eliminating early symptoms of varicose veins. The purpose of the study was to examine the range of medicines and supplements used for the symptomatic treatment of veno-lymphatic insufficiency in the Ukrainian market. The study of the range of medicines for the symptomatic treatment of veno-lymphatic insufficiency in Ukraine was carried out using a content analysis of the State Register of Drugs. The following scheme was used to study the set of drugs and dietary supplements with venotonic effect: analysis of drugs by ATX classification, dosage form, composition, country and manufacturer. The main research methods used were marketing, statistical and graphical. The results of the analysis of ATC-group C05 «Angioprotectors» showed that 35 drugs of various dosage forms from eight countries with venotonic effect were registered in the pharmaceutical market of Ukraine. The largest number of trade names is registered in the group of bioflavanoids, in particular Troxerutin C05C A04 (22.85%), Diosmin, combinations C05C A53 (17.14%), Escin, combinations C05C X51 (17.14%). The group Heparin or heparinoids for topical use C05B A03 (60%) can be separately distinguished, which are also used in the complex treatment of varicose veins. In the domestic market, the share of Ukrainian-made phlebotonics prevails (51.42%), represented by tablets and soft dosage forms (22.85%), capsules and oral drops (2.85%). German-made drugs are represented by oral drops (8.57%), tablets and capsules (2.85% each), Bulgarian drugs are topical products, including gels (8.57%) and tablets, and French drugs are represented by capsules only (8.57%). The pharmaceutical market of Ukraine has about 26. The supplements are represented by flavonoid fractions of diosmin and hesperidin (39.8%), diosmin (7.14%), combined supplements containing plant extracts, quercetin, ascorbic acid, sodium heparin, troxerutin, rutin, in the form of tablets and capsules of Ukrainian and foreign production.
Source: Farmatsevtychnyi zhurnal
Authors: Г. І. Крамар, О. В. Макаренко, О. І. Альчук
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4409456448