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Tailored Therapeutic Approach in a Patient With Diffuse Large B‐Cell Lymphoma With Meningeal Infiltration, Concurrent Classic Hodgkin Lymphoma, and Smoldering Multiple Myeloma: A Case Report

Year: 2025

Type: article

Abstract: BACKGROUND: Coexisting primary hematologic malignancies in untreated multiple myeloma (MM) are rare. CASE: A 69-year-old man with smoldering multiple myeloma (sMM) presented with lymphadenopathies and an intracranial mass. He was diagnosed with diffuse large B-cell lymphoma (DLBCL), classic Hodgkin lymphoma (cHL), and sMM. The patient received R-CHOP and R-ICE, followed by autologous stem cell transplantation, achieving complete remission of DLBCL and cHL, and very good partial remission of MM. CONCLUSION: This case illustrates the complexity of managing multiple malignancies and the importance of a tailored therapeutic approach.

Source: Cancer Reports

DOI: 10.1002/cnr2.70102

Authors: Giusy Ceparano, Daniele Lorenzini, Maurilio Ponzoni, Giorgia Levati, Davide Epifania, Vincenzo Marasco

Institutions: University of Milan, Fondazione IRCCS Istituto Nazionale dei Tumori, IRCCS Ospedale San Raffaele

Language: English

Topic: Multiple and Secondary Primary Cancers

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,280