Year: 2025
Type: article
Abstract: Carbon fiber/polyetheretherketone (CF/PEEK) has been widely used in the field of bone repair.However, its bio-inert nature results in poor osseointegration, which significantly limits its long-term stability and bone repair efficacy in clinical applications.Here, a manganese-doped nano-hydroxyapatite (Mn/nHA) coating was constructed on the surface of CF/PEEK using a liquid-phase self-assembly strategy of inorganic nanoparticles.The experimental results demonstrated that both Mn/nHA and nHA coatings significantly improved the surface roughness and hydrophilicity of CF/PEEK.Further in vitro studies revealed that after 7 days of co-culture with rat mesenchymal stem cells, the relative cell viability of the Mn/nHA and nHA-coated materials reached as high as 180% and 159%, respectively, compared to the blank control, indicating a pronounced pro-proliferative effect.Additionally, alizarin red staining and reverse transcription-polymerase chain reaction (RT-PCR) analysis showed that both coatings enhanced cell mineralization and osteogenic differentiation on the material surface, with the Mn/nHA coating exhibiting a stronger promoting effect.
Source: Journal of Inorganic Materials
DOI: 10.15541/jim20250078
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4409460597