Work

PDE7 as a Precision Target: Bridging Disease Modulation and Potential PET Imaging for Translational Medicine

Year: 2025

Type: article

Abstract: Phosphodiesterase 7 (PDE7) regulates cAMP-PKA signaling and plays a crucial role in immune function, neuroprotection, and inflammation. Dysregulated PDE7 activity is linked to neurodegenerative, autoimmune, and metabolic disorders, making it a promising therapeutic target. Recent advancements in PDE7 inhibitors, particularly pyrimidinone-based compounds, have shown high selectivity and potent biological effects. Beyond therapeutics, radiolabeled PDE7 inhibitors offer potential for PET imaging, enabling noninvasive disease monitoring and treatment assessment.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.5c00160

Authors: Taoqian Zhao, Steven H. Liang

Institution: Emory University

Language: English

Topic: Phosphodiesterase function and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500