Global, Regional, and National Incidence and Prevalence of Children With Peptic Ulcer Disease: A Temporal Trend and Bayesian Age‐Period‐Cohort Analysis Based on the 2021 Global Burden of Disease Study
Year: 2025
Type: article
Abstract: BACKGROUND: Identifying temporal trends in children with peptic ulcer disease (PUD) could enhance public awareness and inform future policy development. METHODS: Utilising data from GBD 2021, we analysed the incidence, prevalence and age-specific rates (ASR) of children with PUD from 1990 to 2021, conducting stratified analyses based on regional temporal variations. A Bayesian age-period-cohort (BAPC) model was employed to project the global burden of children with PUD over the next 15 years. RESULTS: Globally, both the incidence and prevalence of children with PUD exhibited a marked decline, with incidence and prevalence cases decreasing by 0.93% and 3.67%, respectively. Regions with lower sociodemographic index (SDI) bore a heavier burden, with the highest incidence and prevalence observed in Oceania, Western sub-Saharan Africa and the Caribbean in 2021. By 2035, the global incidence and prevalence of children with PUD are projected to further decline. CONCLUSION: While the global burden of children with PUD had significantly decreased, regional disparities persist. Low-SDI countries continue to face disproportionately high incidence and prevalence rates, warranting sustained attention and intervention.
DOI: 10.1111/jpc.70058
Authors: Haosen Cui, Congfeng Xu, Yue Fan, Zhanyu Wang
Institution: Anhui Medical University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4409463587