Work

Odontogenic brain abscess caused by Porphyromonas gingivalis and Streptococcus constellatus : a case report and review article

Year: 2025

Type: article

Abstract: Background Odontogenic brain abscess is a rare, but potentially fatal, central nervous system infection, with insidious onset and unclear etiology.Methods This case reports a 70-year-old male patient who developed an odontogenic brain abscess secondary to periodontal infection and underwent neurological surgery. Extract pus during surgery for the metagenomic next-generation sequencing (mNGS).Results The mNGS of pus samples obtained from brain abscess aspiration identified the periodontal pathogens Porphyromonas gingivalis and Streptococcus constellatus. Consequently, he was referred to the department of stomatology for further examination and treatment.Conclusions Our study found that major periodontal pathogens including P. gingivalis and S. constellatus were essential in the development of odontogenic brain abscesses; thus, timely intervention and preventive measures are important for treatment.

Source: Journal of Oral Microbiology

DOI: 10.1080/20002297.2025.2485197

Authors: Siyu Sun, Rui He, Shan Chen, Jing Ren, Xinrong Ma, Junying Yang

Institution: Sun Yat-sen University

Language: English

Topic: Otolaryngology and Infectious Diseases

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,428