Work

Progressive Weight Loss-Induced Remission of Insulin Resistance/Hyperinsulinemia and Improvements in Cardiovascular Risk Factors

Year: 2025

Type: article

Abstract: Background: Hyperinsulinemia (HI) is a common endocrine metabolic disorder in obesity and is closely associated with cardiovascular disease. Aim: This study aims to investigate the effects of progressive weight reduction on HI and cardiovascular risk factors. Methods: We enrolled 68 patients with overweight or obesity. Body composition assessments, clinical indicator sampling and a 75g-oral glucose tolerance test were conducted at baseline and after 12-month weight loss to assess HI and insulin sensitivity. And the people were divided into four groups based on the percent of weight loss (< 10%, ~20%, ~30%, > 30%) to study the remission of HI and changes in body composition and cardiovascular risk factors. Results: A total of 66 participants were studied at the end. Progressive weight loss significantly reduced plasma glucose and insulin ( P < 0.001, P for trend < 0.001) and did not progressively reduce cardiovascular risk factors ( P for trend < 0.001). The greater the percentage of weight loss, the greater the remission rate of insulin resistance and hyperinsulinemia ( P for trend < 0.001), which reaches 100% when weight loss exceeds 30%. After adjusting for factors such as age, gender, and medication usage, remission of HI was still associated with progressive weight loss. Conclusion: With progressive weight loss, people with overweight or obesity experienced further improvements in glycemic outcomes, body compositions, HI and insulin resistance. Keywords: hyperinsulinemia, obesity, Insulin resistance, weight loss, body composition

Source: Diabetes Metabolic Syndrome and Obesity

DOI: 10.2147/dmso.s501876