Year: 2025
Type: article
Abstract: This review explores the research progress of G protein-coupled receptors (GPCRs) in neurological diseases, highlights the central role of GPCRs in the regulation of cognitive function and mood, and discusses their potential therapeutic potential in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. This review also covers the importance of adhering GPCRs (aGPCRs) in neurodevelopment and discusses the application of structural biology, gene editing, and artificial intelligence in GPCR drug development. Future studies will focus on revealing the detailed mechanism of action of GPCRs to develop more effective therapies.
Source: Biomedical Data Science
Author: Youming Zhuo
Institution: Guangdong Medical College
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4409465438