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Relationship Between Mutation Profile Detected by Next-generation Sequencing and Histopathological Parameters in Lung Squamous Cell Carcinoma

Year: 2025

Type: article

Abstract: Lung Squamous cell carcinoma (LSCC) represents the second most common non-small cell lung cancer. Although studies identified adenocarcinoma-like driver mutations in LSCC using next-generation sequencing (NGS), the disease is challenging to treat due to the limited number of detectable mutations for targeted drug therapy. This study aimed to evaluate the mutation profiles of LSCC detected by NGS to assess the relationships between different driver mutations and clinicopathological parameters.

Source: Journal of Clinical and Translational Pathology

DOI: 10.14218/jctp.2025.00001

Authors: Nesibe Kahraman Çetin, Ezgi Özkıran, Sinan Can Taşan, Dilara Akın, İbrahim Halil Erdoğdu, İbrahim Meteoğlu

Institutions: Adnan Menderes University, İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4409467621