Work

Discovery of Novel SHP2 ATTEC Degraders against Pancreatic Ductal Adenocarcinoma Harboring KRAS(G12D) Mutations

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.4c02682

Authors: Yue Zhong, Yan Lu, Jiahui Li, Qiang Ren, Yiqing Fan, Xiqi Meng, Jieyu Shao, Hai Qian

Institutions: China Pharmaceutical University, State Key Laboratory of Natural Medicine

Language: English

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Government of Jiangsu Province

Awards: G2176797573, G839422118

OpenAlex ID: W4409481183

FWCI: 2.268

Cites: 31

Cited by: 9

Related to: 10