Work

A Prospective Open‐Label Study of Tolerance and Effectiveness of Sequential Dermocosmetic Treatments Combining Poly‐ l ‐Lysine Biovectors With Vitamins A and C

Year: 2025

Type: article

Abstract: Background and Objectives: Atopic dermatitis (AD) is a common chronic inflammatory skin condition, affecting 15%-20% of children and up to 10% of adults. It has a significant impact on patients' quality of life and represents a considerable burden on healthcare systems. Management strategies aim to restore the skin barrier, reduce inflammation, and achieve physiological and homeostatic balance. This study evaluates the safety and efficacy of a new dermocosmetic formulation combining poly-l-lysine biovectors with vitamins A and C. Methods: A single-arm, open-label study was conducted on 20 patients diagnosed with AD, including 14 women and 6 men aged between 24 and 63, with skin phototypes of Fitzpatrick I-VI. Treatment involved sequential application of poly-l-lysine G2/vitamin C in the morning and poly-l-lysine G3/vitamin A in the evening for 28 days, on the face, hands, and body. Outcomes were assessed using the Dermatology Life Quality Index (DLQI) and SCORAD scores. Additional assessments included a visual analog scale for pruritus and sleep disturbance, as well as patient self-report questionnaires on skin improvement and treatment satisfaction. Results: = 1.05) scores. Objective improvements included reductions in erythema (-50%), dryness (-60%), and pruritus (-50%). Conclusion: This study demonstrates the potential of poly-l-lysine-based dermocosmetics combined with vitamins A and C to improve the symptoms and quality of life of patients suffering from AD. The formulations were well-tolerated and effective in restoring the skin barrier and reducing inflammation. Further large-scale controlled studies are needed to validate these results and explore long-term efficacy.

Source: Health Science Reports

DOI: 10.1002/hsr2.70676

Authors: Bertrand Nassar, Hafid Belhadj‐Tahar, Weiyang Jin, Guanghua Yang

Institution: Shanghai Ocean University

Language: English

Topic: Dermatology and Skin Diseases

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,280