Work

Deep Brain Stimulation of the VIM for Tremor in a Patient with POLR3A-Associated Cerebellar Syndrome Without Long-Term Benefit

Year: 2025

Type: article

Abstract: Background: Deep brain stimulation is an approved therapy for essential tremor and Parkinson's disease. In addition, VIM-DBS is used off-label for the treatment of tremor syndromes with a different etiology. Case Report: We present the case of a woman with a drug-refractory action tremor due to rare compound heterozygous POLR3A mutations. Her treatment with VIM DBS did not lead to a sustained improvement of symptoms. Discussion: Tremor due to POLR3A-related cerebellar syndromes may not be responsive to VIM DBS. The networks contributing to cerebellar tremor should be better investigated in terms of where neuromodulatory therapy might be more effective.

Source: Tremor and Other Hyperkinetic Movements

DOI: 10.5334/tohm.1003

Authors: Ute Scheller, Steffen Paschen, Fabian Maass, Christoph van Riesen

Institutions: Universitätsmedizin Göttingen, Christian-Albrechts-Universität zu Kiel, University Hospital Schleswig-Holstein, German Center for Neurodegenerative Diseases

Language: English

Topic: Neurological disorders and treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $800