Caplacizumab treatment in elderly patients with iTTP: Experience from the Spanish TTP Registry
Year: 2025
Type: article
Study design: Observational Study
Abstract: Immune thrombotic thrombocytopenic purpura (iTTP) typically affects middle‐aged individuals, although it sometimes appears in older patients. Caplacizumab is approved for the treatment of iTTP, but information on the safety and efficacy of this drug in elderly patients is not available. We aimed to analyze the management and outcomes of iTTP patients registered in the Spanish TTP Registry and receiving caplacizumab at any time during the acute episode, focusing on patients ≥60 years (n = 29) and comparing them with patients <60 years (n = 70). Severe bleeding motivated caplacizumab's initiation delay in one patient ≥60 years. Patients receiving anticoagulation or antiplatelet therapy at diagnosis were more common in older patients (10% vs. 1%; p = 0.074), as well as the occurrence of bleeding motivating caplacizumab discontinuation (17% vs. 1%, respectively; p = 0.008). Caplacizumab seemed to be efficient in the treatment of iTTP in older patients, reducing refractoriness and death to 3% and exacerbation to 10%, similar to younger patients. The higher risk of bleeding in this older population warrants the need for close monitoring during treatment and to further explore the best management of thrombotic and bleeding risk.
Source: HemaSphere
DOI: 10.1002/hem3.70109
Authors: Inés Gómez‐Seguí, Joan Cid, Miquel Lozano, Maria Eva Mingot‐Castellano, Cristina Pascual‐Izquierdo, Luz Maria Gonzalez del Castillo, Julia Maria Vidan Estevez, Faustino Garcia‐Candel, Moraima Jiménez Balarezo, David Valcarcel, Clara Cuellar Perez‐Avila, Maria Arraiz Ramirez, Sunil Lakhwani, Maria Gemma Moreno Jimenez, Ana Yurena Oliva Hernandez, Jose Maria Garcia Gala, Jorge Martinez Nieto, Rosa Goterris, Marta Fernández Docampo, Clara Sopeña Pell‐Ilderton, Javier de la Rubia
Institutions: Hospital Universitari i Politècnic La Fe, Hospital Clínic de Barcelona, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Hospital General Universitario Gregorio Marañón, Hospital Universitario de Gran Canaria Doctor Negrín, Hospital Universitario de León, Hospital Universitario Virgen de la Arrixaca, Vall d'Hebron Hospital Universitari, Hospital Universitario 12 De Octubre, Donostiako Unibertsitate Ospitalea, Hospital Universitario de Canarias, Hospital Universitario Ramón y Cajal, Hospital Universitario Nuestra Señora de Candelaria, Hospital Universitario Central de Asturias, Hospital Clínico San Carlos, Hospital Clínico Universitario de Valencia, Complexo Hospitalario Universitario A Coruña, Valencia Catholic University Saint Vincent Martyr, Instituto de Investigación Sanitaria La Fe
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,480
OpenAlex ID: W4409485678