MaDDFLOSY(Mass Determination via Diffusion in FLow Ordered SpectroscopY) for the Determination of Diffusion-Averaged Molecular Weight of Polymers in Continuous Motion Using Benchtop NMR
Year: 2025
Type: article
Abstract: Real-time determination of the molecular weight of polymers synthesized in continuous flow or indeed in any process is essential for efficient and sustainable process chemistry. Typically achieved through online chromatographic techniques, such methods are often prone to perturbations, require large volumes of solvents, have lengthy acquisition times, and can result in significant process inefficiencies. We demonstrate the use of diffusion-ordered NMR spectroscopy (DOSY NMR) calibration on a 60 MHz benchtop to measure the molecular weight of polymers while in laminar flow. We then utilized this technique to monitor batch polymerization progress in real time.
Source: Macromolecules
Authors: William Pointer, Owen Tooley, Asad Saib, Rowan Radmall, Paul Wilson, Daniel Lester, James Town, Robin J. Blagg, David Haddleton
Institutions: University of Warwick, Oxford Instruments (United Kingdom)
Language: English
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Awards: G1238289555, Sustainable Chemicals Innovations Enabling Net Carbon Emissions (SCIENCE), G2718074677, G2798898976, EPRSC Resource Only Strategic Equipment: the Warwick Analytical Science Centre, G4685944227, EPSRC Centre for Doctoral Training in Molecular Analytical Science, G5725318496, EPSRC Core Equipment Award 2020: University of Warwick, G6207847509, G6920694809, G987229451
OpenAlex ID: W4409486351