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Association of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study

Year: 2025

Type: article

Abstract: Dementia-related blood biomarkers are the future of large-scale dementia risk stratification; however, the extent to which phosphorylated tau (P-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) are associated with nonmodifiable risk factors has yet to be confirmed in the community, and the role of menopause has yet to be investigated. Therefore, the aim of this study was to examine the association of age, sex, APOEe4 status, and menopause, with dementia-related blood biomarker levels (P-tau181, NfL, and GFAP) and rate of change over 11 years in longitudinal biomarker measurements in community-dwelling adults.

Source: Neurology

DOI: 10.1212/wnl.0000000000213500

Authors: Hannah Stocker, Léon Beyer, Kira Trares, Joshua Stevenson-Hoare, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Ben Schoettker, Klaus Gerwert, Hermann Brenner

Institutions: German Cancer Research Center, Ruhr University Bochum, Medical University of Vienna, Krebsregister Saarland, Heidelberg University

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4409487595

FWCI: 5.084

Cites: 43

Cited by: 8

Related to: 10