Work

One Carbon at a Time: Unlocking Iterative Carboxylic Acid Homologation

Year: 2025

Type: article

Abstract: The development of a direct and iterative protocol for carboxylic acid homologation has constituted a long-standing challenge in synthesis. We recently disclosed an efficient and practical strategy for the homologation of unmodified carboxylic acids, which exploits the visible-light photoredox reactivity of nitroethylene. This Synpacts article aims to provide an overview of the motivation behind the design of the homologation strategy and the key insights of its development. 1 Introduction: Homologation Background and Relevance 2 Development of a Direct, Iterative Carboxylic Acid Homologation 2.1 Identifying an Optimal C2-Radical Acceptor for Carboxylic Acid Homologation 2.2 Visible-Light Decarboxylation of Unmodified Carboxylic Acids 3 Conclusion

Source: Synlett

DOI: 10.1055/a-2589-5229

Authors: Mattia Silvi, Emilie Wheatley

Institution: University of Nottingham

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: UK Research and Innovation, University of Nottingham, Engineering and Physical Sciences Research Council

Awards: G6462348439, Light-Driven Multicomponent C-C Couplings: New Avenues to Bioactive Molecules