Work

Leptospirosis and coinfections leading to fatal multiple organ and system failure

Year: 2025

Type: article

Abstract: Coinfection with leptospirosis and other infectious agents pose major challenges in medical practice, often due to difficulties in isolating these agents, symptoms overlap, and lack of specific investigation protocols in areas with emerging and re-emerging diseases. Consequently, knowledge regarding these coinfections and their impact on clinical outcomes are limited. A previously healthy 33-year-old woman, with no history of chronic or malignance diseases, was admitted with febrile icteric illness, pulmonary hemorrhage, acute kidney injury, thrombocytopenia, and shock. Leptospirosis, COVID-19, human rhinovirus, and dengue in the acute phase were clinically and pathologically diagnosed. Multiple coinfections can rapidly lead to multiple organ and system failure, often resulting in a fatal outcome.

Source: Revista do Instituto de Medicina Tropical de São Paulo

DOI: 10.1590/s1678-9946202567026

Authors: Luiza Schettini Marotto, Marcia Schettini Marotto, Tomás Zecchini Barrese, Cinthya dos Santos Cirqueira Borges, Juliana Mariotti Guerra, Leonardo José Tadeu de Araújo, Camila Santos da Silva Ferreira, Amir Nassar Filho, Paulo Cesar Fumagalli Marotto

Institutions: Instituto Adolfo Lutz, Instituto de Assistência Médica ao Servidor Público Estadual, Universidade Nove de Julho

Language: English

Topic: Leptospirosis research and findings

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409490543

FWCI: 0.828

Cites: 15

Cited by: 1

Related to: 10